941 research outputs found

    The interactions of cholinergic and anticholinergic drugs with nigro-neostriatal dopaminergic neurons

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    Enrollment Report - Fall 1990

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    The Enrollment Report provides administrative and delivery-site information on enrollment headcount and student credit hours, as well as the demographic characteristics of enrolled students. The purpose of this profile is to provide the undergraduate and graduate enrollments and student credit hour information by college or equivalent academic unit, class, gender and ethnicity

    Informationsverarbeitung im Rahmen der JahresabschlussprĂźfung: Fachkonzeptuelles Modell eines integrierten Anwendungssystems zur UnterstĂźtzung der JahresabschlussprĂźfung

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    Gegenstand der vorliegenden Untersuchung ist es, die Jahresabschlussprßfung als Prozess der Informationsverarbeitung darzustellen und diesen Prozess zu analysieren. Es wird betrachtet, ob und auf welche Art und Weise durch zielorientierte Konstruktion eines Anwendungssystems zur Unterstßtzung der Abschlussprßfung die Effektivität und Effizienz des Prßfungsprozesses erhÜht werden kann. Dabei werden ausgehend von einer Informationsbedarfsanalyse sämtliche denkbaren MÜglichkeiten des Einsatzes prßfungsunterstßtzender Anwen-dungssysteme untersucht. Auf dieser Basis wird im Hauptteil der Untersuchung ein fachkonzeptuelles Modell eines prßfungsunterstßtzenden Anwendungssystems unter Zugrunde-legung der ARIS-Methode modelliert. Die Arbeit wurde im Jahre 2002 an der wirtschaftswissenschaftlichen Fakultät der TU Dresden als Dissertation angenommen

    Dynamical Instabilities and Deterministic Chaos in Ballistic Electron Motion in Semiconductor Superlattices

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    We consider the motion of ballistic electrons within a superlattice miniband under the influence of an alternating electric field. We show that the interaction of electrons with the self-consistent electromagnetic field generated by the electron current may lead to the transition from regular to chaotic dynamics. We estimate the conditions for the experimental observation of this deterministic chaos and discuss the similarities of the superlattice system with the other condensed matter and quantum optical systems.Comment: 6 pages, RevTEX; 4 fig

    Anisotropic permeability in deterministic lateral displacement arrays

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    We uncover anisotropic permeability in microfluidic deterministic lateral displacement (DLD) arrays. A DLD array can achieve high-resolution bimodal size-based separation of microparticles, including bioparticles, such as cells. For an application with a given separation size, correct device operation requires that the flow remains at a fixed angle to the obstacle array. We demonstrate via experiments and lattice-Boltzmann simulations that subtle array design features cause anisotropic permeability. Anisotropic permeability indicates the microfluidic array's intrinsic tendency to induce an undesired lateral pressure gradient. This can cause an inclined flow and therefore local changes in the critical separation size. Thus, particle trajectories can become unpredictable and the device useless for the desired separation task. Anisotropy becomes severe for arrays with unequal axial and lateral gaps between obstacle posts and highly asymmetric post shapes. Furthermore, of the two equivalent array layouts employed with the DLD, the rotated-square layout does not display intrinsic anisotropy. We therefore recommend this layout over the easier-to-implement parallelogram layout. We provide additional guidelines for avoiding adverse effects of anisotropy on the DLD.Comment: 13 pages, 10 figures, 1 table, DLD, particle separation, microfluidics, anisotropic permeabilit

    Can filesharers be triggered by economic incentives? Results of an experiment

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    Illegal filesharing on the internet leads to considerable financial losses for artists and copyright owners as well as producers and sellers of music. Thus far, measures to contain this phenomenon have been rather restrictive. However, there are still a considerable number of illegal systems, and users are able to decide quite freely between legal and illegal downloads because the latter are still difficult to sanction. Recent economic approaches account for the improved bargaining position of users. They are based on the idea of revenue-splitting between professional sellers and peers. In order to test such an innovative business model, the study reported in this article carried out an experiment with 100 undergraduate students, forming five small peer-to-peer networks.The networks were confronted with different economic conditions.The results indicate that even experienced filesharers hold favourable attitudes towards revenue-splitting.They seem to be willing to adjust their behaviour to different economic conditions

    Breakdown of deterministic lateral displacement efficiency for non-dilute suspensions: a numerical study

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    We investigate the effect of particle volume fraction on the efficiency of deterministic lateral displacement (DLD) devices. DLD is a popular passive sorting technique for microfluidic applications. Yet, it has been designed for treating dilute suspensions, and its efficiency for denser samples is not well known. We perform 3D simulations based on the immersed-boundary, lattice-Boltzmann and finite-element methods to model the flow of red blood cells (RBCs) in different DLD devices. We quantify the DLD efficiency in terms of appropriate "failure" probabilities and RBC counts in designated device outlets. Our main result is that the displacement mode breaks down upon an increase of RBC volume fraction, while the zigzag mode remains relatively robust. This suggests that the separation of larger particles (such as white blood cells) from a dense RBC background is simpler than separating smaller particles (such as platelets) from the same background. The observed breakdown stems from non-deterministic particle collisions interfering with the designed deterministic nature of DLD devices. Therefore, we postulate that dense suspension effects generally hamper efficient particle separation in devices based on deterministic principles.Comment: 21 pages, 9 figure

    Building Science Gateways for Analysing Molecular Docking Results Using a Generic Framework and Methodology

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    Molecular docking and virtual screening experiments require large computational and data resources and high-level user interfaces in the form of science gateways. While science gateways supporting such experiments are relatively common, there is a clearly identified need to design and implement more complex environments for further analysis of docking results. This paper describes a generic framework and a related methodology that supports the efficient development of such environments. The framework is modular enabling the reuse of already existing components. The methodology, which proposes three techniques that the development team can use, is agile and encourages active participation of end-users. Based on the framework and methodology, two prototype implementations of science-gateway-based docking environments are presented and evaluated. The first system recommends a receptor-ligand pair for the next docking experiment, and the second filters docking results based on ligand properties
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